Dr Murphy Wan
Biography
Dr. Wan completed her PhD at the University of Hong Kong before joining Lund University, Sweden, as a Postdoctoral Fellow, where she investigated the transcriptional regulation of disease severity in bacterial kidney infections.
She is currently a Senior Lecturer in Biomedical Sciences at the 小蓝视频. Since establishing her research lab in 2021, her work has focused on developing novel therapeutics for cancer and neurodegenerative diseases, leveraging cutting-edge precision medicine approaches. Her lab integrates multi-omics technologies鈥攊ncluding genomics, transcriptomics, proteomics, and metabolomics鈥攖o uncover the molecular mechanisms underlying complex diseases.
Dr. Wan has published in high-impact journals, including Nature Biotechnology, Nature Communications, ACS Pharmacology & Translational Science, Critical Reviews in Food Science and Nutrition, and Scientific Reports. She is frequently invited to review manuscripts for leading journals and present her research at international conferences. Additionally, she serves as an active member and Network Coordinator of the ARUK South Coast Network.
Research interests
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Natural Compounds in Cancer Therapy 鈥 Investigating the therapeutic potential of bioactive molecules in colorectal cancer, supported by funding from the Academy of Finland.
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Targeting Cancer Signaling Pathways 鈥 Identifying and developing novel small-molecule compounds through computational biology, advanced bioinformatics, and cancer cell biology.
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Neuroinflammation and Alzheimer鈥檚 Disease 鈥 Exploring the role of bacterial infections and systemic inflammation in Alzheimer鈥檚 disease. Supported by the ARUK South Coast pump-priming grant, this research investigates amyloid-beta in the gut-brain-microbiota axis, examining how bacterial infection and inflammation contribute to disease development and identifying novel therapeutic targets.
More information can be found at https://www.mwanlab.com/
Dr Murphy Wan welcomes MRes and PhD students. Please email murphy.wan@port.ac.uk to discuss further.
Research outputs
2025
Co, V. A., El-Nezami, H., Lee, P., Wan, M. L. Y., Yang, Y., Zhao, D.
1 Jan 2025, In: Food Chemistry. 463, 9p., 141371
2024
Agbodjan-Dossou, R., Co, V. A., Cox, P. A., Dey, P., Draheim, R., El-Nezami, H., Joseph, S., Liu, Y., Sabzichi, M., Twum, B., Wan, M. L. Y.
8 Mar 2024, In: ACS Pharmacology & Translational Science. 7, 3, p. 863-877
Ahmadi, S., Ambite, I., Carneiro, A. N. B. M., Cavalera, M., Chaudhuri, A., Esmaeili, P., Grossi, M., H谩膷ek, J., Svanborg, C., Tran, T. H., Wan, M.
15 Feb 2024, In: Scientific Reports. 14, 21p., 3838